Acute Encephalitis Syndrome: Causes and Lapses | 19 Jun 2019

More than 100 children in Bihar’s Muzaffarpur district have died of acute encephalitis syndrome (AES), with the state’s medical authorities initially blaming the deaths on the heat wave, hypoglycemia (sudden drop in blood sugar levels) and lack of awareness. Now, belatedly, they have acknowledged the two most critical causes for the deaths — malnutrition and the inadequacy of primary health centres (PHCs).

The AES cases in Muzaffarpur, Bihar and adjoining litchi producing districts have been observed every year in summers(mostly from April to June), particularly in children who are undernourished with a history of visiting litchi orchards.

Causes: Litchi is being most commonly blamed for the Acute Encephalitis Syndrome (AES) outbreak in Bihar. However, experts are of the view that fruit is only a triggering factor for malnourished children as the toxin methylenecyclopropyl glycine (MCPG) can lead to hypoglycaemia (fall in sugar levels) in undernourished children that in turn results into unconsciousness, coma and even death.

• Malnutrition cause hypoglycaemia: Malnourished children have depleted glycogen store in the liver. So if there is no glycogen reserve, the glycogen breaks into glucose and when the shortage further increases, even fats start burning and this process produces by products like ketones and amino acids which are neurotoxic and are responsible for inflammation of the brain tissue.
• Heat waves: when temperature and humidity were recorded over consecutive days at more 38 degrees Celsius and 50% respectively, the epidemic had been at its worse. In other parts of northern India there is fluctuation in temperature and humidity, and the nights are cooler, but in Muzaffarpur humidity increases at night making it worse than the day, especially for children.
• The main causative agents of acute encephalitis are the viruses like herpes viruses, enteroviruses, West Nile, Japanese encephalitis, Eastern equine viruses, tick-borne viruses etc.
• Encephalitis is also caused due to bacteria, fungi or parasites, chemicals, toxins and non-infectious agents.

The death of children in Muzaffarpur due to AES, a preventable disease, shows the inaction of the state machinery, which has failed to take appropriate steps to prevent the seasonal outbreak of disease.

Lapses

• Primary health centres: the first point of healthcare for most AES patients are ill-equipped to deal with the disease.
  
  • Most of them do not have, virology lab or adequate number of paediatric beds and glycometers to monitor blood sugar levels.
• Standard operating procedure : to treat AES, have clearly not been implemented in Bihar, which mandates grassroots health workers, including auxiliary nurse-midwives, accredited social health activists, and anganwadi workers, to do daily household-level surveys to check children for JE/AES symptoms during the outbreak season from June to September.
• Lack of preparedness: of the state government in terms special nutrition programme for AES-prone areas (as undernourished children are more prone to the disease).
• Inadequate Machinery: Unavailability of doctors, beds, intensive care units, medical professionals to deal with an epidemic level situation which has resulted in more than 126 reported death of children in the state of Bihar particularly in Muzaffarpur and its adjoining areas.

Way Forward

• Surveillance and Monitoring: of AES vulnerable region ( for identifying AES prone cases) is necessary for early diagnosis and treatment of disease.
  
  • AES can be contained if the child is administered dextrose within 4 hours of the onset of symptoms
  • 10% Dextrose infusion within the golden hours can speed up the pace of recovery.
• Awareness campaigns and symptom management: as a pre-emptive measures must be put in place for dealing with the AES cases.
  
  • State Government should learn from the dastak initiative (for treating Japanese Encephalitis) taken by Uttar Pradesh, that has brought together health, rural development and primary education officials to promote clean drinking water, sanitation, vaccination and early referral to hospitals for treatment through symptom management.
• Infrastructural and Institutional set up: Primary Health Care centres must be equipped with all necessary equipments and amenities that are crucial for diagnosing and treating AES patients.
• Medical Research and Studies: conducted in AES prone regions that are crucial for establishing link between causes and symptoms of the disease must be taken into account for formulating treatment strategy.
• Special Nutrition programmes: and mid day meals must be implemented in the AES prone regions as it has been identified that toxins in litchi is just a triggering factor in the already malnutritioned children.