CAR T-cell Therapy | 09 Feb 2023

Why in News?

The main treatments for cancer are surgery, radiotherapy and systemic therapy.

• Surgery and radiotherapy have improved over time, but advances in systemic therapy have been particularly impressive, with Chimeric antigen receptor (CAR) T-cell therapy being a recent breakthrough attracting global attention.

What are the Major Interventions in Systemic Therapy for Cancer Treatment?

• Systemic therapy began with chemotherapy, which attacks cancer cells due to their fast growth.
  • Chemotherapy drugs have limited success and significant side effects because they affect many types of cells in the body.
• The next advancement was targeted agents, also known as immunotherapy, which work by binding to specific targets on the cancer or immune cells supporting its growth.
  • This approach is less toxic as it affects fewer non-tumor cells, but only works on tumours that have these targets.

What is CAR T-cell Therapy?

• About:
  • CAR T-cell therapies are a major breakthrough in cancer treatment.
    • Unlike chemotherapy or immunotherapy which involve taking drugs, CAR T-cell therapies use a patient's own cells. They are modified in the laboratory to activate T-cells and target tumor cells.
  • CAR T-cell therapy has been approved for leukaemias (cancers arising from the cells that produce white blood cells) and lymphomas (arising from the lymphatic system).
• Procedure:
  • T cells are taken from a patient’s blood and then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added to the T cells in the laboratory.
    • The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion.

• Significance:
  • CAR T-cell therapies are even more specific than targeted agents and directly stimulate the patient's immune system to fight cancer, leading to greater clinical efficacy.
    • That's why they're referred to as "living drugs."
• Challenges:
  • Preparation:
    • The difficulty of preparing CAR T-cell therapies has been a major hindrance to their widespread use.
    • The first successful clinical trial was published a decade ago, and the first indigenously developed therapy in India was performed in 2021.
  • Side Effects:
    • In certain kinds of leukaemias and lymphomas, the efficacy is as high as 90%, whereas in other types of cancers it is significantly lower.
    • The potential side-effects are also significant, associated with cytokine release syndrome (a widespread activation of the immune system and collateral damage to the body’s normal cells) and neurological symptoms (severe confusion, seizures, and speech impairment).
• Affordability:
  • Introduction of CAR T-cell therapy in India can face challenges of cost and value.
  • Critics argue that developing CAR T-cell therapy in India may not be cost-effective as it will still be unaffordable for most people.

Source: TH